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Does Stem Cell Therapy Promise Cure for Multiple Sclerosis?

Today, Cleveland, Ohio, is a place where takes place a very essential research carried out by the physicians. Case Western Reserve University started researchments of the stem cell treatment usage for curing multiple sclerosis. There are big hopes that stem cells will be capable to interchange and rebuild the harmed brain tissue, replacing the reason of the ailment and easing it.

Injecting the examines with their own bone marrow stem cells is really a rough method, for no one knows precisely how or due to what it acts. The main purpose of the research was to give answers to many questions concerning the process, after successful implementation of it on mice. Prof. Robert Miller of the Case Western Reserve University headed the project.

What is Multiple Sclerosis?

Multiple sclerosis is an autoimmune ailment, when your immunity starts to assault the myelin cover of the nerves. This makes nerves to become thinner and weaker and lose the capability to pass signals from the brain and back to it, consequently inducing loss of movements and coordination functions.

Recent Researches on Multiple Sclerosis

The recent test was targeted to show the opportunity to rebuild the harmed myelin nerve covers, treating the ailment forever. Miller’s group, just as many others, did not know of the precise mechanism of SC’s action. They only knew that mice had recovered after transplantation of human stem cells.

multiple-sclerosisIn May, the physicians have finally found the effluent of the stem cells curing effect: it was the large molecule, named the hepatocyte growth factor or HGF, concealed by the SCs into the surrounding medium. Prof. Miller said that this HGF secret is the main clue to recovering the harmed areas.

It was detected, while mice were given only the medium, where the cells grew, without any cells. Consequently, the experts had concluded that the curing agent areas in the medium. And so, after detailed analysis, the HGF was uncovered.

To be really sure that this agent is exactly what they needed, the first ill mouse was injected with a big dosage of HGF and felt much better afterwards within a short period of time. The second one had a block upon HGF acceptors and though it received the same dosage, remained ill. That was a very evident conferment, said Prof. Miller.

Afterwards HGF was given to examinees and the results were bettered greatly. 16 of 24 had sufficiently enhanced their functioning and 8 of them passed the trial protocol, reported DR. Jeffrey Cohen, the major investigator of the project results.

Currently, the team is targeted to improve the effectuality of the HGF to assure the firm and dependable betterment of the ailment’s condition and give new hope to the examinees. These methods mean direct input of the molecule into harmed areas to make the wasting of curing agent throughout the organism minimal and sustain its output where it is needed most.